Mitochondria, the cellular powerhouses, have fascinated scientists for over a century. Among the pioneers, *Otto Warburg* stands tall. In the 1920s, Warburg discovered that cancer cells rely heavily on glycolysis, even in oxygen-rich environments—a phenomenon now known as the Warburg Effect. His work earned him the 1931 Nobel Prize in Physiology or Medicine.
Another luminary, *Peter Mitchell*, revolutionized our understanding of mitochondria with his Chemiosmotic Theory in 1961. Mitchell proposed that ATP synthesis is driven by a proton gradient across the mitochondrial membrane. Initially met with skepticism, his theory was later vindicated, earning him the 1978 Nobel Prize in Chemistry.
These trailblazers laid the groundwork for modern mitochondrial research, proving that even the smallest organelles can spark the biggest discoveries.